Ryan's time on the show was particularly memorable due to there being ten niners available in her octochamp run - one of the highest numbers of niners available to any player in the history of the show. Because of this, the total number of points available to Ryan in her octorun was 1093, matching the record held by Glen Webb's run in Series 69. Ryan is also considered to be one of the greatest female players in the show's history, up there with the likes of Jen Steadman, Tricia Pay and Heather Styles.
Ryan began her run by impressively dispatching of two-time winner Rachel Evans. This game was notable for having a potential ambulance available - three back-to-back nines. Ryan managed one of the three, MISPLACED, and ended up with a very impressive debut score of 107. Ryan went on to achieve six more centuries, being helped along by brilliant spots such as PRIMROSE, PANTIHOSE, PERIANTH and VIRGATES. Ryan also performed impeccably in the numbers rounds, managing to score in every single one of the 32. Ryan dropped below 100 only once, in her seventh game. In the game, against Peter Douet, Ryan was held back by Douet's offering of GERBILS and by Douet unscrambling the conundrum STAGNATED in just nine seconds. Ryan finished with a comfortable 58-point win against Matt Willock, landing her as the #2 seed with 859 points - just two above the now #3 seed Tricia Pay.
Ryan returned (just six days later) to defend her unbeaten crown in the series quarterfinals, against #7 seed David Stanford. The game was surprisingly close throughout, however Ryan managed to break away on the final numbers round, giving her the win. Her semifinal was also a close contest against #6 seed Laurence Killen, notable for Ryan and Killen being equidistant in opposite directions from the target in three of the game's four numbers rounds. However it was Ryan that took the game, outshining Killen in the letters rounds with AILERON and SOAKAGE. The excitement didn't end there, as Ryan's next game would be the series final, against the - seemingly invincible - Dan McColm. McColm took an early lead with the word SOLATIUM, however Ryan fought back by solving a numbers round that McColm didn't, landing her a 2-point lead after six rounds. Her advantage, however, didn't last long, as Ryan made a couple of risks that didn't pay off, giving McColm a 20-point lead before the final numbers round. Ryan's favourite numbers selection of six small didn't prove to help her, and with McColm also solving the conundrum LETHALITY in just four seconds, Ryan was declared the series runner-up.
In 2015, Ryan reappeared in the studio, this time appearing as a contestant on 8 out of 10 Cats Does Countdown Series 6, Episode 9, assisting Sean Lock and Seann Walsh. She didn't drop a point in the 3 rounds she took part in. Ryan made a second return in 2016 for CoC XIV, losing to Mark Murray in the "Battle of the Leprechauns".
|#||Date||Type||Contestant 1||Score||Contestant 2||Guest||Lex||Max|
|6040||26/11/2014||P||Rachel Evans||65 – 107||Antoinette Ryan||Len Goodman||Susie Dent||157|
|6041||27/11/2014||P||Antoinette Ryan||120 – 33||Tom Jordan||Len Goodman||Susie Dent||134|
|6042||28/11/2014||P||Antoinette Ryan||103 – 28||Kevin Duckworth||Len Goodman||Susie Dent||123|
|6043||1/12/2014||P||Antoinette Ryan||104 – 79||Emma Brown||Len Goodman||Susie Dent||145|
|6044||2/12/2014||P||Antoinette Ryan||118 – 51||Bob Currie||Len Goodman||Susie Dent||157|
|6045||3/12/2014||P||Antoinette Ryan||104 – 68||Justin Ray||Alistair McGowan||Susie Dent||120|
|6046||4/12/2014||P||Antoinette Ryan||91 – 48||Peter Douet||Alistair McGowan||Susie Dent||124|
|6047||5/12/2014||P||Antoinette Ryan||112 – 54||Matt Willock||Alistair McGowan||Susie Dent||133|
|6051||11/12/2014||QF||Antoinette Ryan||82 – 65||David Stanford||Arlene Phillips||Susie Dent||121|
|6055||18/12/2014||SF||Antoinette Ryan||102 – 88||Laurence Killen||David Baddiel||Susie Dent||132|
|6056||19/12/2014||GF||Dan McColm||117 – 87||Antoinette Ryan||David Baddiel||Susie Dent||129|
& Sean Lock
|47 – 29||Joe Wilkinson|
& Danny Dyer
|Bill Bailey||Susie Dent||58|
|6285||13/01/2016||CP||Antoinette Ryan||88 – 125||Mark Murray||John Inverdale||Susie Dent||140|