|Conundrums solved||7 (+1 tiebreak)|
Latchford first appeared on 1 February 2021 against Conor Morgan, winning the game on a tie-break conundrum with 82 points. From here, he continued an unbeaten run of 7 more wins, including a personal best of 115 points. In his seventh game, he was three points behind at the crucial conundrum against Arran Smith, but after Smith buzzed in with an incorrect guess, Latchford buzzed in with half a second left with TARANTULA to win. Ultimately, he became the second octochamp of the series with a total of 732 points.
Latchford returned for the finals in June as No. 3 seed, despite officially having 6 points fewer than No. 4 seed Louis Ross. Latchford's practice on Apterous clearly paid dividends, as he took a dominant victory in the third quarter-final over No. 6 seed Declan McGurk without losing a round. He next squared off against No. 2 seed James Burley in the second semi-final, and achieved a seeding "upset" by building a good lead early on and winning by 17 points to advance to the Grand Final against top-seeded prospect Luke Boynton.
In the Grand Final – Nick Hewer's last show as presenter – Latchford held his nerve and immediately led 6 – 0 after Boynton had pawless ☓ disallowed in the first letters round. Latchford then took another 10 points off Boynton in the first numbers game, won two more letters rounds, and only lost one letters round throughout the game. Latchford beat Boynton in the last numbers round prior to the conundrum WASNOMORE, which Boynton solved, and Latchford lifted the Richard Whiteley Memorial Trophy at the end of the show after winning 86 – 101. He is also the last recipient of the Oxford English Dictionaries, which have since been axed from the show due to the books being out of date.
With a total of 1,014 points – an average of 92.18 per game – Latchford has the lowest cumulative series point total for a champion of a 15-round series (Series 46 notwithstanding as only a maximum of 6 preliminary wins were allowed then).
|#||Date||Type||Contestant 1||Score||Contestant 2||Presenters||Guest||Lex||Max|
|7434||1/02/2021||P||Conor Morgan||72 - 82*||Adam Latchford||Colin Murray||Rachel Riley||Adrian Chiles||Susie Dent||137|
|7435||2/02/2021||P||Adam Latchford||87 - 49||Aneesh Aggarwal||Colin Murray||Rachel Riley||Adrian Chiles||Susie Dent||121|
|7436||3/02/2021||P||Adam Latchford||115 - 51||Jacky Treacy||Colin Murray||Rachel Riley||Jenny Eclair||Susie Dent||148|
|7437||4/02/2021||P||Adam Latchford||95 - 56||Chiedza Mutongwizo||Colin Murray||Rachel Riley||Jenny Eclair||Susie Dent||126|
|7438||5/02/2021||P||Adam Latchford||96 - 40||Charles Biggs||Colin Murray||Rachel Riley||Jenny Eclair||Susie Dent||122|
|7439||8/02/2021||P||Adam Latchford||100 - 62||Louis Moen||Colin Murray||Rachel Riley||Jenny Eclair||Susie Dent||123|
|7440||9/02/2021||P||Adam Latchford||82 - 75||Arran Smith||Colin Murray||Rachel Riley||Jenny Eclair||Susie Dent||155|
|7441||10/02/2021||P||Adam Latchford||85 - 70||Jeremy Bradley||Nick Hewer||Rachel Riley||Pasha Kovalev||Susie Dent||145|
|7534||21/06/2021||QF||Adam Latchford||99 - 40||Declan McGurk||Nick Hewer||Rachel Riley||Rufus Hound||Susie Dent||137|
|7537||24/06/2021||SF||James Burley||65 - 82||Adam Latchford||Nick Hewer||Rachel Riley||Rufus Hound||Susie Dent||118|
|7538||25/06/2021||GF||Luke Boynton||86 - 101||Adam Latchford||Nick Hewer||Rachel Riley||Rufus Hound||Susie Dent||125|